Randy Blakely Biography
Dr. Blakely received his B.A. in Philosophy summa cum laude from Emory University, followed by a Ph.D. in Neuroscience from the Johns Hopkins School of Medicine, where he pursued studies of brain peptides with Dr. Joseph T. Coyle. Following his graduate work, Dr. Blakely pursued postdoctoral training at the Yale/HHMI Center for Molecular Neuroscience with Dr. Susan Amara, research that identified the genes encoding targets of widely used antidepressant medications and psychostimulants, including cocaine and amphetamines. As an independent investigator (Emory University, 1990-1995; Vanderbilt University, Allan D. Bass Chair, 1995-2016, Florida Atlantic University, 2016-present), Dr. Blakely has pursued studies of the genetics, structure, regulation and pathophysiology of synaptic transporters, work that appears in more than 300 research articles and scholarly reviews. In recent years, his work has focused on the identification of human transporter mutations that alter neurotransmitter inactivation and/or drug recognition, work that has led to the generation of animal models of multiple neurologic and neuropsychiatric disorders such including autism, ADHD, Alzheimer’s disease and congential myasthenias. A committed mentor to junior scientists, Dr. Blakely has trained nearly 100 undergraduate, Masters, Ph.D. and M.D. students, as well as nearly 40 post-doctoral fellows, many of whom hold independent, leadership positions in academia or industry. Dr. Blakely’s research has been continually funded by the National Institutes of Health and private research foundations for over 30 years.
Dr. Blakely’s research and mentorship have garnered multiple honors including the Daniel Efron Award from the ACNP, two Distinguished Investigator Awards from the Brain and Behavioral Research Foundation, a MERIT Award from the NIMH, a Zenith Award from the Alzheimer’s Association and both the Astellas Award in Translational Pharmacology and the Julius Axelrod Award from ASPET. As Director of the Vanderbilt Center for Molecular Neuroscience, he formed the Vanderbilt Brain Institute and Vanderbilt Neuroscience Ph.D. Program in 1997 with Elaine Sanders-Bush Ph.D., and served for 12 years as the Director of the Vanderbilt Postdoctoral Training Program in Functional Neurogenomics until his departure from FAU in 2016. From 2008-2016, he led the NIMH-sponsored Silvio O. Conte Center for Neuroscience Research at Vanderbilt University. In 2016, Dr. Blakely moved to Florida Atlantic University as Professor of Biomedical Sciences in the Charles E. Schmidt College of Medicine and as the inaugural Executive Director of the FAU Brain Institute. In his role as Executive Director, Dr. Blakely sets Institute priorities for research, education and outreach, oversees the development and acquisition of research infrastructure, leads recruitment efforts for Brain Institute Investigators, among other activities. Dr. Blakely is responsible for a dozen patents related to his gene discoveries and attempts to translate his findings into novel animal models and therapies. In 2009, Dr. Blakely was elected a Fellow of the American Academy for the Advancement of Science. In 2015, he received the Delores C. Shockley Partnership Award in recognition of minority trainee mentorship. In 2017, Dr. Blakely was elected to serve on the National Advisory Mental Health Council for the National Institute of Mental Health and was elected to the National Academy of Invesntors. In 2019 he received the Southeastern University Research Association’s Distinguished Researcher Award and a Lifetime Achievement Award in STEM Education by the Cox Science Center and Aquarium. In 2021, Blakely was awarded the David J.S. Nicholson Distinguished Professorship in Neuroscience at Florida Atlantic University.
MC 17 / Room 109
5353 Parkside Drive
Jupiter, FL 33458
Map of campus
The Blakely Lab at FAU
PubMed Journal & Articles
Localization of brain neuronal IL-1R1 reveals specific neural circuitries responsive to immune signaling.
Nemeth DP, Liu X, Monet MC, Niu H, Maxey G, Schrier MS, Smirnova MI, McGovern SJ, Herd A, DiSabato DJ, Floyd T, Atluri RR, Nusstein AC, Oliver B, Witcher KG, Juste Ellis JS, Yip J, Crider AD, McKim DB, Gajewski-Kurdziel PA, Godbout JP, Zhang Q, Blakely RD, Sheridan JF, Quan N.
J Neuroinflammation. 2024 Nov 19;21(1):303. doi: 10.1186/s12974-024-03287-1.
PMID: 39563437
Forward genetic screen of the C. elegans million mutation library reveals essential, cell-autonomous contributions of BBSome proteins to dopamine signaling.
Refai O, Rodriguez P, Gichi Z, Blakely RD.
J Neurochem. 2024 Sep;168(9):2073-2091. doi: 10.1111/jnc.16188. Epub 2024 Aug 8.
PMID: 39118406
Glial swip-10 controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis.
Rodriguez P, Kalia V, Fenollar-Ferrer C, Gibson CL, Gichi Z, Rajoo A, Matier CD, Pezacki AT, Xiao T, Carvelli L, Chang CJ, Miller GW, Khamoui AV, Boerner J, Blakely RD.
Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2320611121. doi: 10.1073/pnas.2320611121. Epub 2024 Sep 17.
PMID: 39288174
Forward genetic screen of the C. elegans million mutation library reveals essential, cell-autonomous contributions of BBSome proteins to dopamine signaling.
Refai O, Rodriguez P, Gichi Z, Blakely RD.
Front Mol Biosci. 2024 Apr 17;11:1366259. doi: 10.3389/fmolb.2024.1366259. eCollection 2024. J Neurochem. 2024 Aug 8. doi: 10.1111/jnc.16188.
PMID: 39118406
Novel anti-inflammatory effects of the IL-1 receptor in kidney myeloid cells following ischemic AKI.
Chen Y, Lu X, Whitney RL, Li Y, Robson MJ, Blakely RD, Chi JT, Crowley SD, Privratsky JR.
Front Mol Biosci. 2024 Apr 17;11:1366259. doi: 10.3389/fmolb.2024.1366259. eCollection 2024.
PMID: 38693918
Long COVID-19 and Peripheral Serotonin: A Commentary and Reconsideration.
Anderson GM, Cook EH, Blakely RD, Sutcliffe JS, Veenstra-VanderWeele J.J
Inflamm Res. 2024 Apr 11;17:2169-2172. doi: 10.2147/JIR.S456000. eCollection 2024.
PMID: 38628604
Simple Rescue of Opaque Tissue Previously Cleared by iDISCO.
Mesa H, Meade J, Gajewski-Kurdziel P, Blakely RD, Zhang Q.
Bio Protoc. 2024 Mar 5;14(5):e4948. doi: 10.21769/BioProtoc.4948. eCollection 2024 Mar 5.
PMID: 38464943
Optical Imaging Demonstrates Tissue-Specific Metabolic Perturbations in Mblac1 Knockout Mice.
Ceyhan B, Nategh P, Neghabi M, LaMar JA, Konjalwar S, Rodriguez P, Hahn MK, Gross M, Grumbar G, Salleng KJ, Blakely RD, Ranji M.
IEEE J Transl Eng Health Med. 2024 Jan 15;12:298-305. doi: 10.1109/JTEHM.2024.3355962. eCollection 2024.
PMID: 38410184
Functional and pathological consequences of being fast on the uptake: Protein kinase G and p38α MAPK regulation of serotonin transporters.
Gajeswski-Kurdziel PA, Walsh AE, Blakely RD.
Curr Res Physiol. 2024 Jan 4;7:100117. doi: 10.1016/j.crphys.2024.100117. eCollection 2024.
PMID: 38298474
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors.
Gradisch R, Schlögl K, Lazzarin E, Niello M, Maier J, Mayer FP, Alves da Silva L, Skopec SMC, Blakely RD, Sitte HH, Mihovilovic MD, Stockner T.
Nat Commun. 2024 Jan 10;15(1):417. doi: 10.1038/s41467-023-44637-6.
PMID: 38195746