2014 Publications
Mergy MA, Gowrishankar R, Gresch PJ, Gantz SC, Williams J, Davis GL, Wheeler CA, Stanwood GD, Hahn MK, Blakely RD. The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior and alters in vivo responses to psychostimulants. Proc Natl Acad Sci USA, 2014 Nov 4;111(44):E4779-88 [PMID: 25331903; PMCID: PMC4226116]
Bowton E, Saunders C, Reddy IA, Campbell NG, Hamilton PJ, Henry LK, Coon H, Sakrikar D, Veenstra-VanderWeele JM, Blakely RD, Sutcliffe J, Matthies HJ, Erreger K, Galli A. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry. 2014 Oct 14;4:e464. doi: 10.1038/tp2014.90. [PMID: 25313507; PubMed - in process].
Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Mol Psychiatry. 2014 Sep 9. doi 10.1038/mp.2014.98. Epub ahead of print. [PMID: 25199916; PubMed - as supplied by publisher].
Prosser RA, Stowie A, Amicarelli M, Nackenoff AG, Blakely RD, Glass JD. Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN. Neuroscience. 2014 Sep 5;275:184-93. doi: 10.1016/j.neuroscience.2014.06.012. Epub 2014 Jun 17. [PMID: 24950119; PMCID: PMC4122660].
Hardaway JA, Wang J, Fleming KA, Whitaker SM, Nackenoff A, Snarrenberg CL, Hardie SL, Zhang B, Blakely RD. An open-source analytical platform for analysis of C. elegans swimming-induced paralysis. J Neurosci Methods. 2014 May 2:232C:58-62. doi: 10.1016/j.neumeth.2014.04.024 Epub ahead of print [PMID: 24792527; PMCID: PMC4179448].
Blakely RD, Ortega A, Robinson MB. The brain in flux: genetic, physiologic, and therapeutic perspectives on transporters in the CNS. Neurochem Int. 2014 Jul;73:1-3. doi: 10.1016/j.neuint.2014.04.008. Epub 2014 Apr 18. No abstract available. [PMID: 24751395; PubMed - in process].
Berry AS, Demeter E, Sabhapathy S, English BA, Blakely RD, Sarter M, Lustig C. Disposed to Distraction: Genetic Variation in the Cholinergic System Influences Distractibility But Not Time-on-Task Effects. J Cogn Neurosci. 2014 Mar 25. Epub ahead of print [PMID: 24666128; PubMed – in process].
Vollbrecht PJ, Simmler LD, Blakely RD, Deutch AY. Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1. J Neurochem, 2014 Jul;130(1):109-14. doi: 10.1111/jnc.12697, Epub 2014 Mar 18 [PMID: 24611756; PMCID: PMC4065617].
Ye R, Carneiro AM, Han Q, Airey D, Sanders-Bush E, Zhang B, Lu L, Williams R, Blakely RD. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes Brain Behav. 2014 Mar;13(3):261-75. doi: 10.1111/gbb.12119. Epub 2014 Feb 6 [PMID: 24405699; PubMed – in process].
Rudnick G, Krämer R, Blakely RD, Murphy DL, Verrey F. The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch. 2014 Jan;466(1):25-42, doi: 10.1007/s00424-013-1410-1. Epub 2013 Dec 13 [PMID: 24337881, PMCID: PMC3930102].
Mergy MA, Gowrishankar R, Davis GL, Jessen TN, Wright J, Stanwood GD, Hahn MK, Blakely RD. Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: On the path to an animal model of attention-deficit hyperactivity disorder. Neurochem Int. 2014 Jul;73:56-70. doi 10/1016/j.neuint.2013.11.009. Epub 2013 Dec 8 [PMID: 24332984; PMCID: PMC 4177817].
Holmstrand EC, Lund D., Cherian AK, Wright J, Martin RF, Ennis EA, Stanwood GD, Sarter M, Blakely RD. Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance. Neurochem Int. 2014 Jul;73:217-28. doi: 10.1016/j.neuint.2013.11.008. Epub 2013 Nov 22 [PMID: 24274995; PMCID: PMC4104494].
Gowrishankar R, Hahn MK, Blakely RD. Good riddance to dopamine: Roles for the dopamine transporter in synaptic function and dopamine-associated brain disorders. Neurochem Int. 2014 Jul;73:42-8. doi: 10.1016/j.neuint.2013.10.016. Epub 2013 Nov 11 [PMID: 24231471; PubMed – in process].
Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B, Blakely RD. Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain Behav. 2014 Mar;13(3):247-60. doi: 10.1111/gbb.12092. Epub 2013 Oct 31 [PMID: 24102824; PMCID: PMC3979832].